The final concentrations of Asp and Mg2 + in aqueous components were 7.5 and 5 mM, respectively. Diethylene glycol succinate stationary phase is a non-volatile liquid phase. It is found that the phase formation and spectral properties including quantum efficiency are highly sensitive to sintering temperature and the role of citric acid both as a chelating agent and as a fuel for combustion was … Polyesters of low molecular weight with OH group contents ranging from 3 to 0.5 … DEG is produced by the partial hydrolysis of ethylene oxide. Please call (401) 360-2800 for details. Additionally, it has been used as an illegal adulterant in wine. Marraffa, in Encyclopedia of Toxicology (Third Edition), 2014. It is also used as a humectant in the tobacco industry and in the treatment of corks, glue, paper and cellophane as well as in the synthesis of morpholine and 1,4-dioxane. Diethylene glycol (DEG) is a commonly used agent but a less common toxin than ethylene glycol. Autopsy was performed in one patient with no evidence of oxalate crystals. Application Sensory nerve abnormalities did not show a length-dependent distribution, and a proximo-distal type of motor axonal degeneration was observed. From: Encyclopedia of Toxicology (Second Edition), 2005, J.M. Based on these data it is be reasonable to conclude that the toxicity and treatment of ethylene glycol and diethylene glycol toxicity are similar, at least in rats (a reasonably good animal model). PEG is also known as polyethylene oxide (PEO) or polyoxyethylene (POE), depending on its molecular weight. 1.6 mL H 2 O, MgCl 2 (5 mM), and l-aspartic acid (Asp) (7.5 mM, pH 8.00) aqueous solutions were added into 1.24 mL DEG to study their individual influence, respectively. Structure, properties, spectra, suppliers and links for: Diethylene glycol, 111-46-6. n = 0 ethylene glycol ("antifreeze") ; n = 1 DEG n = 2 triethylene glycol, TEG, or triglycol is also a colorless odourless viscous liquid. Synthesized ACC was dispersed into diethylene glycol (DEG) with a concentration of 3.95 mg/mL. DIETHYLENE GLYCOL is incompatible with strong oxidizing agents. Di(ethylene glycol) dimethacrylate. If you don't need to use it for that … Synonyms:. A Keggin-type heteropoly acid revealed high catalytic activities for the etherification of diethylene glycol with ethanol to synthesize diethylene glycol ether in the homogeneous phase. It is miscible in water, alcohol, ether, acetone, and ethylene glycol. DIETHYLENE GLYCOL is incompatible with strong oxidizing agents. Diethylene glycol (DEG) is an organic compound with the formula (HOCH2CH2)2O. The zero point for the timescale was set at the injection of amino acids. Industrially, DEG is used to manufacture polyurethanes, plasticizers, and polyester resins. Although there is little reported experience in humans, both early dialysis and the inhibition of ADH is recommended for all symptomatic diethylene glycol exposures, especially patients with acidemia or renal insufficiency.67,70 Using fomepizole to inhibit ADH is rational,71 and has been used empirically in human cases.69,70 The toxicity of the parent compound suggests that fomepizole without hemodialysis is unwise. It is not susceptible to photolysis on soil surface, but is expected to biodegrade quickly in both soil and water. Poly(ethylene glycol) (PEG) is a synthetic, hydrophilic, biocompatible polymer with widespread use in biomedical and other applications. Poly(ethylene glycol) diacrylate (PEGDA) oligomers of varying molecular weights (Mn = 3400, 6000, 10,000, and 20,000) were synthesized as described in [23,24]. The resonance signals arising from aromatic protons in 1,n 1–3 were identified in 1H NMR spectra of TPA-DEG condensates. Uses Medical uses. PREVENT GENERATION OF MISTS! DEG is a widely used solvent. Ethylene glycol (EG) is an important organic compound and chemical intermediate used in a large number of industrial processes (e.g. Ethylene glycol (EG) is an important organic compound and chemical intermediate used in a large number of industrial processes (e.g. 1.6 mL H2O, MgCl2 (5 mM), and l-aspartic acid (Asp) (7.5 mM, pH 8.00) aqueous solutions were added into 1.24 mL DEG to study their individual influence, respectively. To examine the switching effect of Asp, 1.36 mL of MgCl2 (5.88 mM) aqueous solution was first added into 0.94 mL DEG. There is also great variability in susceptibility to diethylene glycol poisoning, suggesting pharmacodynamics and individual risk factors are important [12]. In addition to being versatile, Legacy's diethylene glycol fuel cells are convenient and easy to use. Diethylene glycol is used as a dehydrating agent for natural gas, a raw material for the production of plasticizers and polyester resin, and a widely used solvent. A patient in an acute condition appears inebriated but has no alcohol on his or her breath. It is a colorless, low viscosity, low volatile liquid that is sweet to taste. They are derived from ethylene oxide and are described with the formula HO-CH 2-CH 2 (-O-CH 2-CH 2) n-OH: . 0.76 mL ACC–DEG slurry was injected into the reaction solutions and the samples were withdrawn periodically. adipic acid, and diethylene glycol and zinc acetate as a catalyst. The product is completely soluble in water, acetone, alcohol, and other organic solvents. DEG is primarily synthesized via the partial hydrolysis of ethylene oxide, and is co-produced with ethylene glycol and triethylene glycol. Laboratory findings include elevated serum osmolality, hypoglycemia, elevated blood urea nitrogen and creatinine, anion gap metabolic acidosis, elevated liver function test results, and an abnormal urinalysis result with cells and casts. However, the number of studies was limited. Depending on the conditions, varying amounts of DEG and related glycols are produced. Jinhui Tao, in Methods in Enzymology, 2013. DEG is widely used as a solvent for textile dyes, paint pigments, resins, oils, and printing. The exact mechanism of renal toxicity, acidosis, and other aspects of the poisoning are unknown. DEG is produced by the partial hydrolysis of ethylene oxide. Diethylene glycol poisoning can also result in hepatic disease, pancreatitis, and neurologic abnormalities, which appear up to a few days after exposure [8,12]. Availability of DEG depends on the demand for derivatives of the primary product, ethylene glycol, rather than on DEG market requirements. The initiation of fomepizole therapy may also be a useful therapeutic adjunct.20, Joshua A. Bornhorst, Michael M. Mbughuni, in Critical Issues in Alcohol and Drugs of Abuse Testing (Second Edition), 2019. U.S. Federal Regulations TSCA 12(b) Not applicable SARA 313 Not applicable SARA 311/312 Hazard CategoriesSee section 2 for more information CWA (Clean Water Act) Not applicable Clean Air Act Not applicable OSHA Occupational Safety and Health Administration It is a colorless, practically odorless, poisonous, and hygroscopic liquid with a sweetish taste. Toxic effects are thought to result from HEAA accumulation leading to acidosis and organ failure, but the mechanism by which HEAA produces cellular dysfunction and organ failure remains unclear [8,12]. Ethylene glycol is by far the largest volume of the glycol products in a variety of applications. Here diethylene glycol (73%) was used as a vehicle for the preparation of 10% sulfanilamide to treat infections. The animals developed metabolic acidosis as in ethylene glycol toxicity [51] and mortality was reduced if animals were treated with bicarbonate or ethanol. When released to soil or water, diethylene glycol is highly mobile; adsorption to soil and sediment is very low; volatilization is not expected to be important. Use of diethylene glycol in commercial processes in the past century has led to contamination of consumer products, and there have been more than a few epidemics of poisoning since its introduction during the 20th century. Polyp detection was greater and not inferior in the morning-only group. The poison epidemics previously listed have also been associated with liver toxicity, respiratory failure, and seizures. Diethylene glycol has been detected in drinking water, ground water, surface water, and indoor air resulting from its release to the environment from its production and use. The results suggested that the renal tubular damage is due to a toxic metabolite, diglycolic acid, and that transporter-mediated uptake leads to toxic intracellular accumulation. … DEG is produced by the partial hydrolysis of ethylene oxide. Some evidence of this type of reaction is given by the formation of dioxane in low molecular PET and of methyl Cellosolve and methyl carbitol during the ester interchange of DMT with ethylene glycol and diethylene glycol, respectively. TCC’s Diethylene Glycol (DEG) is a straight-chain dihydric alcohol which is aliphatic terminated on both ends by a hydroxyl group. Volatiles were distilled-off under ambient pressure for 3.5 h (run 1 in Table 1). Cookie information is stored in your browser and performs functions such as recognising you when you return to our website and helping our team to understand which sections of the website you find most interesting and useful. 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