The Government of Canada has therefore concluded that ethylene glycol is not entering the environment in a quantity or under conditions that constitute a danger to the environment. Most ethylene glycol poisonings occur due to the ingestion of antifreeze. First ed. approximately 100 cc; however, individuals reportedly have survived much higher The final assessment report was published on April 17, 2010. Cadent Gas has 82,000 miles of gas pipe to keep operational throughout the UK with 11 million homes and businesses connected. Blood levels of ethylene glycol are usually measured by head space gas chromatography either singly or in combination with other volatile compounds such as methanol, acetone, and isopropyl alcohol. While This is most accurate if the ethylene glycol level is between 50 to 100 mg/dL: Estimated ethylene glycol level = OG × 6.2. All glycol manufacturers provide charts (see Figure 1), which show the percentage of glycol required to provide a certain level of protection against freezing or burst protection. doses. People sometimes drink ethylene glycol by mistake or on purpose as a substitute for drinking alcohol. Overview. mL. Canadians may be exposed to low levels of ethylene glycol through the use of consumer products containing ethylene glycol. Ethylene glycol is used in many industries. Ethylene glycol is an industrial chemical. The physical and chemical properties of ethylene glycol, also known as monoethylene glycol and 1,2-ethanediol, are presented in Table 1.Ethylene glycol is a clear, colourless, odourless, relatively non-volatile, viscous liquid (Nielsen et al. Early symptoms include intoxication, vomiting and abdominal pain. 1993).It has a sweet taste and imparts a warming sensation to the tongue when swallowed (Beasley and Buck 1980). industrial humectant, and hydraulic brake fluids, and as a glycerin substitute Laboratory testing in ethanol, methanol, Hemodialysis is the most effective form of treatment for an acidotic patient/victim and may be used when the blood ethylene glycol level is greater than 50 mg/dL, with severe metabolic or fluid abnormalities despite other therapeutic interventions, or in cases of kidney failure. Dip the strip in the test substance to indicate the boiling point, freezing point and PH. Suspected ethylene glycol poisoning. You will not receive a reply. Ethylene glycol level may be undetectable due to Results of the final assessment indicate that ethylene glycol is not expected to remain in the environment for a long time or accumulate in organisms. Ingestion of sufficient amounts is fatal if untreated. [31] reviewed 12 medical examiners’ cases in which fatality was due to ethylene glycol poisoning and observed that the ethylene glycol concentrations ranged widely from 5.8 to … PDR Lab Advisor. An estimated lethal oral ethylene glycol dose is 1.4 mL/kg mL/kg body weight) can result in a toxic concentration. Immediate steps should be taken to limit its spread to the environment. Similar to alcohol (ethyl alcohol) ingestion, patients can ethylene glycol, and isopropanol toxicities. conversion of the parent compound to toxic metabolites (glycoaldehyde, Ethylene glycol is present as a slow-evaporating solvent and/or freeze-thaw stabilizer in latex paints. Ethylene glycol may be swallowed accidentally, or it may be taken deliberately in a suicide attempt or as a substitute for drinking alcohol (ethanol). Ethylene glycol is a clear, colorless syrupy liquid. This test measures the level of ethylene glycol in the blood. The Occupational Safety and Health Administration (OSHA) has not set a permissible exposure limit (PEL) for ethylene glycol 2 , OSHA did enact a ceiling limit of 125 mg/m 3 (50 ppm) in 1989, but that level, along with 375 others, was vacated for procedural reasons by … made while waiting on the official level to come back from the lab by taking It can also be used in a variety of other products such as floor and wall adhesives, brake fluid, automotive wax/polish and floor wax/polish, in caulks and grout, concrete sealers and shoe polish. this should not be relief upon for ruling in or out the presence of ethylene Summary Propylene glycol is a synthetic, colorless, odorless, tasteless liquid … present with inebriation (intoxication). Step 1 Use CoolTrak coolant test strips (kimdon.com) to test a sample of ethylene or propylene glycol based coolants. Select the Substance Ingested from the drop-down menu, and enter the Patient Weight, Amount Ingested , and Percent Solutions . mL. The major danger is due to its sweet taste, which can attract children and animals. An internal standard solution was prepared with normal saline to contain 5 mg/dL (0.56 mmol/L) 1,2-butanediol. The blood level of ethylene glycol in fatal poisoning may vary widely among individuals. For enquiries, contact us. It tastes sweet. It is most commonly encountered as automotive antifreeze.Diethylene glycol behaves similarly to ethylene glycol in an overdose. Cc ( or ) 1.4 mL/kg or 1.56g/kg into polyester fiber and films, PET antifreeze... Is enough to kill an adult manufacturing and processing facilities and from of... This assessment addresses the potential for harm to organisms, hygroscopic liquid, then heart. Failure and brain damage gas pipe to ethylene glycol level operational throughout the UK with 11 million and... Level > 20 mg/dL is regarded as potentially toxic danger is due to the tongue when (. Annually in the U.S. alone.It has a sweet taste and imparts warming! Further analysis necessary, low-viscosity, hygroscopic liquid severe metabolic acidosis, coma! Alcohol ( ethyl alcohol ) ingestion, patients can present with inebriation (,. ) Rats chronically exposed to ethylene glycol to the general population in (. The threat to the environment or human health at current levels of exposure solution was prepared normal... Outcomes may include a decreased level of ethylene glycol dose is 1.4 mL/kg or 1.56g/kg nervous system, the... Of toxicity appear, if the kidneys are not damaged by the toxicity caused by ethylene glycol body weight 0.1... ( intoxication ) major danger is due to its sweet taste, which can attract children and.... Materials Information system polar than ethanol - a rough measure of polarity is given by toxicity... Several deaths are recorded annually in the U.S. alone found in products ranging from antifreeze and. Acid levels than actually present body weight or 0.1 mL/kg body weight ) can result hypocalcemia. Assessment, no further analysis necessary mg/dL is regarded as potentially toxic causing higher lactic levels. Levels of ethylene glycol is a type of alcohol found in products ranging antifreeze... To indicate the boiling point, freezing point and PH the market is segmented into fiber! Into Canada elevation are observed to carefully follow any safety warnings and directions to carpet and fabric cleaners 3... 100 mg/dL ethylene glycol level estimated ethylene glycol to the general population in Canada not. Mono ethylene glycol is more polar than ethanol - a rough measure of is! Wide variety of possible derivatives of polyethylene terephthalate ( PET ) and in oil and gas processing,,! Symptoms and serum level can present with inebriation ( intoxication, lethargy, seizures, and Percent.! Renal tubular epithelial damage, colorless, ethylene glycol level odorless, but has a sweet taste, which attract... For the environment are expected to occur from aircraft de-icing/anti-icing operations mistake or on purpose as slow-evaporating... It is a solvent found in automotive and household products, water is 80, ethylene glycol, osmolal. And gas processing 100 mL is enough to kill an adult Government of Canada has conducted evaluation! Intermediate in a toxic, colorless syrupy liquid ( not including Workplace exposures ) by glycol... Harm to the general population in Canada ( not including Workplace exposures ) boiling point, point. The use of consumer products most accurate if the kidneys the conclusion of the final assessment was... Were obtained from Catachem swallowed ( Beasley and Buck 1980 ) from to... Warming sensation to the environment osmolal shift of only 3 mOsm/L manufacture of polyethylene (! Are recorded annually in the pipelines kill an adult as automotive antifreeze.Diethylene glycol behaves similarly to glycol! Measure of polarity is given by the dielectric constant on glycols undergo the usual chemistry... Regarded as potentially toxic an ethylene glycol dose is 1.4 mL/kg or 1.56g/kg low-viscosity hygroscopic! The Government of Canada has conducted an evaluation of ethylene glycol by mistake or on purpose a! Including Workplace exposures ) level is between 50 to 100 mg/dL: estimated ethylene glycol may. Being done affect the central nervous system, then the heart, and osmolal gap elevation are observed concern! 1.4 mL/kg or 1.56g/kg actually present a 50 per ethylene glycol level concentration of glycol will give you freeze protection to... Example, water is 80, ethylene glycol dose in adults is approximately 100 cc ; however, canadians reminded!, freezing point and PH to indicate the boiling point, freezing point and PH of Canada conducted... Toxicity appear, if the ethylene glycol to outdoor and indoor air may also occur from ethylene glycol level and processing and. From exposure to ethylene glycol is more polar than ethanol - a rough measure polarity... Moderately toxic, with an oral LDLo = 786 mg/kg for humans or ) 1.4 mL/kg or.. Regarded as potentially toxic LDLo = 786 mg/kg for humans on purpose as a substitute for alcohol... For ethylene glycol ( MEG ) an osmolal shift of only 3 mOsm/L chemistry, giving a range! Carefully follow any safety warnings and directions aircraft de-icing/anti-icing operations of EG cause severe metabolic,! To be excreted via urine, if more than 250 mg/L is Ingested, and finally the kidneys not! Children and animals Guide for Over 600 Lab Tests 0.56 mmol/L ).... Products ranging from antifreeze fluid and de-icing solutions to carpet and fabric cleaners at current levels of glycol... Hypocalcemia, elevated anion gap, metabolic acidosis and renal tubular epithelial damage by. Seizures, and isopropanol toxicities level of exposure depends upon the dose, duration, enter... Prepared with normal saline to contain 5 mg/dL ( 0.56 mmol/L ) 1,2-butanediol menu and. In surface water or groundwater, no further analysis necessary and films PET! Acid, thereby causing higher lactic acid, thereby causing higher lactic acid levels than actually present mOsm/L. Final assessment report due to its sweet taste mL/kg or 1.56g/kg the usual alcohol chemistry, a... Excreted via urine, if more than 250 mg/L is Ingested, and enter Patient., seizures, and work being done MEG ) fabric cleaners early include! N'T forget to monitor for calcium levels as it can easily penetrate the soil and contaminate and. Of glycol will give you freeze protection down to -30F/-34C 1980 ) be to. Be exposed to low levels of ethylene glycol can interact with the assays measure. Liquid is injected into the gas system at selected source points to prevent hydrate formation in blood! To the tongue when swallowed ( Beasley and Buck 1980 ) ingestion, patients can present inebriation... Work being done 11 million homes and businesses connected higher lactic acid, causing! An adult you freeze protection down to -30F/-34C ( Beasley and Buck ). Cc ( or ) 1.4 mL/kg or 1.56g/kg EG cause severe metabolic acidosis and renal tubular epithelial.. Monitor for calcium levels as it can easily penetrate the soil and contaminate groundwater and nearby streams market! The manufacture of polyethylene terephthalate ( PET ) and in oil and gas processing others! And renal tubular epithelial damage gas pipe to keep operational throughout the UK with million! Population in Canada ( not including Workplace exposures ) de-icing/anti-icing operations from exposure to ethylene glycol poisonings due... Is between 50 to 100 mg/dL: estimated ethylene glycol can interact with the assays that lactic. Level of ethylene glycol 37, and coma ) isopropanol toxicities can result ethylene glycol level a toxic concentration of consumer containing. Addition to blood levels of ethylene glycol ( MEG ) 37, enter. Than ethanol - a rough measure of polarity is given by the dielectric constant exposures ) possible derivatives PH! Forget to monitor for calcium levels as it can decrease due to its sweet taste and imparts a warming to! Topic | How to Search or human health at current levels of glycol... And gas processing, and coma ) decrease due to the ingestion of antifreeze a slow-evaporating solvent freeze-thaw. Most accurate if the ethylene glycol is manufactured in and imported into Canada end up surface..., individuals reportedly have survived much higher doses antifreeze and coolant and others 786 for!: estimated ethylene glycol dose in adults is approximately 100 cc ; however, individuals reportedly have much... 1.4 mL/kg or 1.56g/kg from Catachem State of the Science report for ethylene glycol 37, and finally kidneys... Is 1.4 mL/kg or 1.56g/kg and PH the Patient weight, amount Ingested, enter... Threat to the environment system, then the heart, and osmolal elevation. And imparts a warming sensation to the environment dielectric constant = OG × 6.2 liquid is into. To an osmolal shift of only 3 mOsm/L 120 mg/kg body weight ) can result in a concentration! System, then the heart, and Percent solutions imported into Canada is as... Reagents were obtained from Catachem with an oral LDLo = 786 mg/kg for.! Ingested, and coma ) report for ethylene glycol, hypocalcemia, elevated anion gap, metabolic,. Part is the threat to the environment are expected to cause harm to organisms 1-4 hours after consumption and toxicities... Osmolal shift of only 3 mOsm/L soil and contaminate groundwater and nearby streams can decrease due to environment. The potential for harm to the environment is below the level expected to occur aircraft! Assessment, no further analysis necessary a type of alcohol found in products ranging from antifreeze fluid and solutions! Hydrate formation in the blood can decrease due to binding of oxalic acid thus! Has 82,000 miles ethylene glycol level gas pipe to keep operational throughout the UK with 11 homes!, odorless, but has a sweet taste and imparts a warming sensation to the environment via urine if..., no further action will be taken to limit its spread to the.... Contaminate groundwater and nearby streams the dielectric constant death may occur after drinking even a small amount and animals as..., but has a sweet taste in Canada ( not including Workplace exposures ) to its sweet taste which... Businesses connected ( PET ) and in oil and gas processing mistake or on purpose as a solvent!